Tumor suppression by miR-31 in esophageal carcinoma is p21-dependent
نویسندگان
چکیده
منابع مشابه
Tumor suppression by miR-31 in esophageal carcinoma is p21-dependent
microRNA regulation network is important for the cancer genetic heterogeneity. Relative to the increasing numbers of microRNA's targets identified, upstream regulatory mechanisms that control functional microRNAs are less well-documented. Here, we investigated the function of miR-31, a pleiotropically-acting microRNA, in esophageal squamous cell cancer (ESCC). We demonstrated that miR-31 only e...
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OBJECTIVES To identify differentially expressed miRNA between oral squamous cell carcinoma (OSCC) and non-cancer (NC) and to associate these with clinico-pathological parameters. MATERIALS AND METHODS miRNA microarray profiling was utilized to obtain the expression profile of miRNAs in four OSCC and four NC samples. The expression of miR-31 and miR-375 was further validated in 26 OSCC and thr...
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15 صفحه اولExpression of p21 in the p53-dependent Pathway Is Related to Prognosis in Patients with Advanced Esophageal Carcinoma
The proteins p53 and p21 are important components that regulate G1-S transition through the cell cycle. We immunohistochemically investigated p53 and p21 expression in 111 patients with esophageal squamous cell carcinoma. We also evaluated whether the expression of either of these proteins is a prognostic factor according to the p53-dependent and -independent pathways. The positive rates of p53...
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ژورنال
عنوان ژورنال: Genes & Cancer
سال: 2014
ISSN: 1947-6027
DOI: 10.18632/genesandcancer.38